Semester-IV

Basic understanding with hands-on training of the various chromatographic techniques

Paper and Thin layer chromatography (TLC)

Gas Chromatography (GC)

High Performance Liquid Chromatography (HPLC)

Gas Chromatography–Mass Spectrometry (GC-MS)

Liquid Chromatography–Mass Spectrometry (LC–MS)

CHO-451: Advanced Synthetic Organic Chemistry

Section I-

1. Structure and stereochemistry of Hardwickiic acid, Camptothecin and podophyllotoxin 

 2. Synthesis of i) Taxol ii) Estrone and Mifepristone  iii) Juvabione (K.Mori and Matsui, Pawson and Cheung Synthesis) iv) Fredericamycin A 

 Section II-

 Biogenesis – The building blocks and construction mechanism of 

 1. Terpenoids – Mono, Sesqui, Di and Triterpenoids and cholesterol

 2. Alkaloids derived from ornithine, lysine, nicotinic acid, tyrosine and tryptophan.

 3. The shikimate pathway – cinnamic acids, lignans and lignin, coumarins, flavonoids and stilbens, isoflavanoids and terpenoid quinones.